Figure 7.

Danegaptide prevents TGFβ1-evoked changes in the secretion of adipokines, chemokines, growth factors and interleukins. Primary hPTECs were cultured in low glucose (5 mM) ± TGFβ1 (10 ng/mL) ± danegaptide (100 nM) for 48 h. An inflammation antibody array was used to assess the secretion of 31 candidate inflammatory proteins in the supernatant from treated hPTECs. Results are representative of 3 separate experiments and presented as the mean ± SEM (n = 3), with key significances indicated (* p < 0.05, ** p < 0.01, *** p < 0.001; one-way ANOVA and Tukey’s post-test).