Table 6.

The effects of sulforaphane on cognitive impairment in Alzheimer’s disease (AD)-like animal models.

Model	Sulforaphane Dose	Findings	Ref.
5×FAD mice	every other day 10 mg/kg i.p. for 2 months	ameliorated cognitive deficits (Morris water maze tests and passive avoidance tests)	[31]
3×Tg-AD mice	every other day 5 or 10 mg/kg i.p. for 2 months	ameliorated cognitive deficits (Morris water maze tests)	[31]
	daily 10 or 50 mg/kg p.o. 6 days/week for 2 months	ameliorated memory deficit (novel object/location recognition tests and contextual fear conditioning tests)	[34]
APP/PS1 mice	daily 25 mg/kg p.o. for 5 months	ameliorated cognitive dysfunction (open field and Morris water maze tests)	[35]
PS1V97L mice	daily 5 mg/kg i.p. for 4 months	alleviated cognitive deficit (Morris water maze tests)	[32]
AD-like mice induced by Aβ1–40	daily 30 mg/kg i.p. for 6 days	ameliorated cognitive function (Y-maze and passive avoidance behavior tests)	[36]
AD-like rat induced by Aβ42	daily 5 mg/kg i.p. for 7 days	improved spatial learning	[37]

i.p., intraperitoneally; p.o., per os (by mouth).