Table 3.
Haplotype analysis of VDR rs7975232, rs1544410, and rs731236 gene variants in patients with postmenopausal osteoporosis (PMO) and control (CON) group.
| Haplotype | Frequency, % | Haplotype Score | p FDR | Logistic Regression | ||
|---|---|---|---|---|---|---|
| PMO | CON | OR (95% CI) | p | |||
| C-C-A | 38.6 | 49.6 | −3.53 | 0.001 | Ref. | - |
| A-T-G | 44.9 | 31.7 | 4.41 | 0.00005 | 1.8 (1.4–2.3) | 0.0001 |
| A-T-A | 4.0 | 7.1 | −1.78 | 0.12 | 0.9 (0.6–1.4) | 0.63 |
| C-C-G | 5.7 | 4.1 | 0.84 | 0.50 | 1.6 (0.9–2.7) | 0.11 |
| A-C-A | 4.2 | 3.5 | 0.15 | 0.88 | 1.3 (0.8–2.2) | 0.34 |
| Rare * | 2.6 | 4.0 | - | - | - | - |
OR, odds ratio; Ref., referent value; CI, confidence interval; FDR, false discovery rate. * Rare haplotypes—other possible haplotypes with total frequency less than 3%. The values highlighted in bold indicate a significant association.