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. 2021 Mar 12;14(3):258. doi: 10.3390/ph14030258

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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N-(p-coumaroyl) serotonin and N-feruloyl serotonin, but not serotonin, decreased the expression of MMP3 and MMP13 induced by IL-1β in articular chondrocytes. Chondrocytes were treated with various concentrations (0, 50, 100, and 200 µM) of serotonin, N-(p-coumaroyl) serotonin, and N-feruloyl serotonin (B). The mRNA expression levels of Mmp3 and Mmp13 were measured by RT-PCR (A,B,C; upper panel) and qRT-PCR (A,B,C; lower panel). Gapdh was used as the loading control. Data are presented as mean ± SD of each group (n = 5). # p < 0.05 compared with the control; * p < 0.05, *** p < 0.001 compared with the IL-1β-, serotonin-, N-(p-coumaroyl) serotonin-, and N-feruloyl serotonin-treated groups.