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SARS-CoV 2 interactions with tRAS. SARS-CoV-2 binding on ACE2 inhibits the conversion of the pathological AngII to protective Ang1–7. The resulting increase in local angiotensin 2 (AngII) concentrations lead to an overactivation of the pathological AngII/angiotensin II receptor type 1 (AGTR1) axis, leading to a cytokine storm and resulting in overwhelming inflammatory reactions [169].
