Table 2.
Antifungal effect of the combination of topical drugs and terbinafine on T. interdigitale.
| Topical Drugs | Strain No. | MIC of Topical Drug (µg/mL) | MIC of Terbinafine (µg/mL) | FIC Index | Drug Interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Alone | With Terbinafine | Alone | With Topical Drug | ||||||||
| Efinaconazole | IFM 62762 | 0.0078 | 0.0020 | − | 0.0078 | 0.0078 | 0.0039 | − | 0.0078 | 0.75 | Additive |
| IFM 62959 | 0.0078 | 0.00098 | − | 0.0039 | 0.0078 | 0.0020 | − | 0.0078 | 0.38 | Synergistic | |
| IFM 63291 | 0.0078 | 0.0020 | − | 0.0039 | 0.0078 | 0.0020 | − | 0.0078 | 0.50 | Synergistic | |
| IFM 63319 | 0.0078 | 0.00049 | − | 0.0078 | 0.016 | 0.0078 | − | 0.016 | 0.56 | Additive | |
| IFM 63830 | 0.00098 | 0.00012 | − | 0.00098 | 0.016 | 0.0039 | − | 0.016 | 0.38 | Synergistic | |
| IFM 64133 | 0.0078 | 0.00049 | − | 0.0078 | 0.031 | 0.0078 | − | 0.031 | 0.31 | Synergistic | |
| IFM 64134 | 0.0078 | 0.00098 | − | 0.0078 | 0.031 | 0.0078 | − | 0.031 | 0.38 | Synergistic | |
| IFM 64902 | 0.0020 | 0.00098 | − | 0.0020 | 0.016 | 0.016 | 1.50 | Indifferent | |||
| FIC index range | 0.31–1.50 | ||||||||||
| Geometric mean FIC index | 0.52 | ||||||||||
| Luliconazole | IFM 62762 | 0.00024 | 0.000061 | − | 0.00024 | 0.0078 | 0.0039 | − | 0.0078 | 0.75 | Additive |
| IFM 62959 | 0.00024 | 0.00012 | − | 0.00024 | 0.0078 | 0.0020 | − | 0.0078 | 0.75 | Additive | |
| IFM 63291 | 0.00024 | 0.00012 | − | 0.00024 | 0.0078 | 0.0039 | − | 0.0078 | 1.00 | Indifferent | |
| IFM 63319 | 0.00049 | 0.000061 | − | 0.00049 | 0.016 | 0.0078 | − | 0.016 | 0.63 | Additive | |
| IFM 63830 | 0.00012 | 0.000061 | − | 0.00012 | 0.016 | 0.0039 | − | 0.016 | 0.75 | Additive | |
| IFM 64133 | 0.00024 | 0.000061 | − | 0.00024 | 0.031 | 0.016 | − | 0.031 | 0.75 | Additive | |
| IFM 64134 | 0.00024 | 0.00012 | − | 0.00024 | 0.031 | 0.016 | − | 0.031 | 1.00 | Indifferent | |
| IFM 64902 | 0.00012 | 0.00012 | 0.0078 | 0.0078 | 2.00 | Indifferent | |||||
| FIC index range | 0.63–2.00 | ||||||||||
| Geometric mean FIC index | 0.89 | ||||||||||
| Tavaborole | IFM 62762 | 4.0 | 0.50 | − | 4.0 | 0.0078 | 0.0078 | 1.13 | Indifferent | ||
| IFM 62959 | 4.0 | 2.0 | 0.0078 | 0.0078 | 1.50 | Indifferent | |||||
| IFM 63291 | 4.0 | 2.0 | − | 4.0 | 0.0078 | 0.0078 | 1.50 | Indifferent | |||
| IFM 63319 | 8.0 | 4.0 | 0.016 | 0.00098 | − | 0.016 | 0.56 | Additive | |||
| IFM 63830 | 4.0 | 2.0 | − | 4.0 | 0.016 | 0.016 | 1.50 | Indifferent | |||
| IFM 64133 | 4.0 | 1.0 | − | 4.0 | 0.031 | 0.016 | − | 0.031 | 0.75 | Additive | |
| IFM 64134 | 4.0 | 4.0 | 0.031 | 0.016 | − | 0.031 | 1.50 | Indifferent | |||
| IFM 64902 | 8.0 | 1.0 | − | 8.0 | 0.0078 | 0.0078 | 1.13 | Indifferent | |||
| FIC index range | 0.56–1.50 | ||||||||||
| Geometric mean FIC index | 1.13 | ||||||||||
MIC: mic minimum inhibitory concentration, FIC: Fractional Inhibitory Concentration. IFM: Institute of Food-Microbiology Chiba Medical College.