Table 3.
Antifungal effect of the combination of topical drugs and itraconazole on T. rubrum.
| Topical Drugs | Strain No. | MIC of Topical Drug (µg/mL) | MIC of Itraconazole (µg/mL) | FIC Index | Drug Interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Alone | With Itraconazole | Alone | With Topical Drug | ||||||||
| Efinaconazole | NBRC 5807 | 0.0020 | 0.00049 | − | 0.0020 | 0.016 | 0.016 | 1.25 | Indifferent | ||
| NBRC 6203 | 0.0020 | 0.00012 | − | 0.00098 | 0.016 | 0.0039 | − | 0.016 | 0.31 | Synergistic | |
| NBRC 9185 | 0.0039 | 0.0020 | − | 0.0039 | 0.016 | 0.016 | 1.50 | Indifferent | |||
| IFM 46636 | 0.0039 | 0.00049 | − | 0.0039 | 0.016 | 0.0039 | − | 0.016 | 0.38 | Synergistic | |
| IFM 47615 | 0.0078 | 0.0039 | − | 0.0078 | 0.031 | 0.016 | − | 0.031 | 1.00 | Indifferent | |
| IFM 47624 | 0.0039 | 0.00098 | − | 0.0039 | 0.016 | 0.0078 | − | 0.016 | 0.75 | Additive | |
| IFM 47625 | 0.0039 | 0.00049 | − | 0.0039 | 0.063 | 0.031 | − | 0.063 | 0.63 | Additive | |
| IFM 46157 | 0.0039 | 0.00024 | − | 0.0039 | 0.031 | 0.031 | 1.06 | Indifferent | |||
| FIC index range | 0.31–1.50 | ||||||||||
| Geometric mean FIC index | 0.76 | ||||||||||
| Luliconazole | NBRC 5807 | 0.00024 | 0.000031 | − | 0.00012 | 0.016 | 0.0039 | − | 0.016 | 0.38 | Synergistic |
| NBRC 6203 | 0.00024 | 0.000031 | − | 0.00024 | 0.016 | 0.0039 | − | 0.0078 | 0.38 | Synergistic | |
| NBRC 9185 | 0.00024 | 0.00024 | 0.016 | 0.016 | 2.00 | Indifferent | |||||
| IFM 46636 | 0.00024 | 0.00012 | − | 0.00024 | 0.016 | 0.0039 | − | 0.016 | 0.75 | Additive | |
| IFM 47615 | 0.00049 | 0.00024 | − | 0.00049 | 0.031 | 0.016 | − | 0.031 | 1.00 | Indifferent | |
| IFM 47624 | 0.00024 | 0.000061 | − | 0.00024 | 0.016 | 0.016 | 1.25 | Indifferent | |||
| IFM 47625 | 0.00024 | 0.00024 | 0.016 | 0.016 | 2.00 | Indifferent | |||||
| IFM 46157 | 0.00024 | 0.000031 | − | 0.00024 | 0.031 | 0.0078 | − | 0.016 | 0.38 | Synergistic | |
| FIC index range | 0.38–2.00 | ||||||||||
| Geometric mean FIC index | 0.82 | ||||||||||
| Tavaborole | NBRC 5807 | 4.0 | 4.0 | 0.016 | 0.0078 | − | 0.016 | 1.50 | Indifferent | ||
| NBRC 6203 | 4.0 | 2.0 | − | 4.0 | 0.0078 | 0.0078 | 1.50 | Indifferent | |||
| NBRC 9185 | 4.0 | 0.13 | − | 4.0 | 0.016 | 0.016 | 1.03 | Indifferent | |||
| IFM 46636 | 4.0 | 0.13 | − | 4.0 | 0.016 | 0.016 | 1.03 | Indifferent | |||
| IFM 47615 | 4.0 | 4.0 | 0.031 | 0.031 | 2.00 | Indifferent | |||||
| IFM 47624 | 4.0 | 1.0 | − | 4.0 | 0.016 | 0.016 | 1.25 | Indifferent | |||
| IFM 47625 | 4.0 | 2.0 | − | 4.0 | 0.016 | 0.016 | 1.50 | Indifferent | |||
| IFM 46157 | 4.0 | 2.0 | − | 4.0 | 0.016 | 0.0078 | − | 0.016 | 1.00 | Indifferent | |
| FIC index range | 1.00–2.00 | ||||||||||
| Geometric mean FIC index | 1.32 | ||||||||||
MIC: mic minimum inhibitory concentration, FIC: Fractional Inhibitory Concentration. NBRC: National Institute of Technology and Evaluation Biological Resource Center, IFM: Institute of Food-Microbiology Chiba Medical College.