Table 1.

Main differences between natural and synthetic materials used in periodontal regeneration.

Synthetic Materials	Natural Materials
Produced through high controlled processes and on large scale	Obtained from different renewable sources
No variation batch to batch	Variation batch to batch
Easy manipulation and purification	Arduous purification processes
High mechanical properties	Poor mechanical properties
Reproducible degradation processes/rate	Unpredictable degradation rate
Low bioactivity and poor cellular adhesion/growth	Biomimetic surface and/or natural remodelling