Table 2.
BCP effects on mitochondrial pathway.
| Treatments | PDH | Citrate Synth | Aconitase | IsocitrateDH | aKGDH | SuccinateDH |
|---|---|---|---|---|---|---|
| CTRL | 1.2111 ± 0.0723 | 1.0100 ± 0.0350 | 0.3211 ± 0.0232 | 1.220 ± 0.0554 | 0.7300 ± 0.0281 | 1.044 ± 0.0423 |
| INS | 1.7566 ± 0.0427 | 1.6955 ± 0.0490 | 0.5600 ± 0.0348 | 2.1711 ± 0.0542 | 1.2078 ± 0.0282 | 1.4644 ± 0.1284 |
| BCP | 1.3122 ± 0.0457 | 1.5177 ± 0.0604 | 0.4422 ± 0.0379 | 1.7855 ± 0.0513 | 1.0422 ± 0.0196 | 1.4277 ± 0.0522 |
| BCP + AM630 | 0.9166 ± 0.0824 | 0.6133 ± 0.0455 | 0.2200 ± 0.0224 | 0.8411 ± 0.0296 | 0.4922 ± 0.0196 | 0.6944 ± 0.0278 |
| AM630 | 0.9511 ± 0.0771 | 0.6277 ± 0.0488 | 0.1989 ± 0.0200 | 0.8266 ± 0.0493 | 0.4911 ± 0.0260 | 0.7011 ± 0.0293 |
| BCP + SR144528 | 0.9837 ± 0.0997 | 0.5125 ± 0.0549 | 0.2350 ± 0.0220 | 0.7162 ± 0.0213 | 0.3738 ± 0.0260 | 0.6525 ± 0.0184 |
| SR144528 | 0.8025 ± 0.0970 | 0.5150 ± 0.0534 | 0.2100 ± 0.0266 | 0.7250 ± 0.0367 | 0.4000 ± 0.0354 | 0.6612 ± 0.0384 |
Values are mean ± SEM of three independent experiments. Values are expressed as nmoles NADH/mg mitochondrial proteins (PDH, isocitrate dehydrogenase, αKG dehydrogenase), nmoles citrate or isocitrate/mg mitochondrial proteins (citrate synthase, aconitase), nmoles FADH2/mg mitochondrial proteins (succinate dehydrogenase).