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. Author manuscript; available in PMC: 2021 Mar 27.
Published in final edited form as: Trends Neurosci. 2020 May 17;43(7):493–504. doi: 10.1016/j.tins.2020.04.007

Figure 3.

Figure 3.

The figure shows a partial list of known functions ascribed to different domains of the tau molecule: N-terminal region (NTR), proline-rich region (PRR), microtubule-binding region (MTBR), and C-terminal region (CTR). These same domains are present in low-molecular-weight (LMW) tau (A) and Big tau (B). The knowledge of these various other domains underscores the unknown function of the large 4a insert of the Big tau molecule. Speculated in (B) are potential functional modifications in the molecule due to the unique presence in Big tau of the large 4a insert in the projection domain. Abbreviation: MT, microtubule.