Table 2.

Analysis of risk factors of ischemic stroke in patients with atrial fibrillation, who suffered a stroke despite NOAC therapy, compared to patients without AF (multivariate logistic regression).

Factors		Univariable Logistic Regression Models				Multivariable Logistic Regression Model *
		OR	Cl 95%	Cl 95%	p	OR	Cl 95%	Cl 95%	p
Age		1.16	1.14	1.18	<0001	1.22	1.18	1.25	<0.001
Gender	Female	2.38	1.79	3.17	<0.001	1.93	1.37	2.70	<0.001
	Male	1.00				1.00
Diabetes mellitus	Yes	2.44	1.87	3.18	<0.001	1.90	1.38	2.63	<0.001
	No	1.00				1.00
Dyslipidemia	Yes	2.12	162	2.77	<0.001	2.48	1.80	3.42	<0.001
	No	1.00				1.00
Hypertension	Yes	4.48	2.78	7.24	<0.001	4.20	2.48	7.10	<0.001
	No	1.000				1.00
Coronary heart disease	Yes	2.78	2.12	3.66	<0.001	1.79	1.27	2.51	0.001
	No	1.00				1.00
Peripheral arterial disease	Yes	1.84	1.31	2.58	<0.001	1.11	0.72	1.71	0.634
	No	1.00				1.00
Smoking	Yes	1.43	1.09	1.86	0.008	2.67	1.91	3.74	<0.001
	No	1.00				1.00
Previous stroke	Yes	2.10	1.60	2.75	<0.001	0.39	0.26	0.60	<0.001
	No	100				1.00

Legend: OR—odds ratio, CI—confidence interval. * Note: Model was adjusted for the following variables: age, sex, diabetes mellitus, dyslipidemia, hypertension, coronary heart disease, peripheral arterial disease, smoking, previous stroke.