Table 4.

Absorption rate of paclitaxel (10 mg/kg) at 10 min after its oral administration with or without P-gp inhibitors in WT and mdr1a/1b KO mice.

	n	+Inhibitor (mg/kg)	Cpv (nM)	Csys (nM)	Cpv − Csys (nM)	Absorption Rate (V) (nmol/min/kg)
WT mice	3		439 ± 98	223 ± 76	216 ± 80	15.7
+Cyclosporin A	5	30	708 ± 77	263 ± 168	534 ± 102	38.7
+LY335979	6	30	1009 ± 149	202 ± 52	830 ± 140	60.2
+WK-X-34	3	30	746 ± 57	196 ± 64	549 ± 7.5	39.8
mdr1a/1b KO mice	6		967 ± 191	218 ± 100	749 ± 165	54.3

Data are represented as mean ± S.D. C_pv: portal vein concentration; C_sys: systemic circulation concentration.