Table 5.
Absorption rate of paclitaxel (10 mg/kg) at 30 min after its oral administration with or without P-gp inhibitor in WT and mdr1a/1b KO mice.
| n | +Inhibitor (mg/kg) |
Cpv (nM) | Csys (nM) | Cpv − Csys (nM) | Absorption Rate V (nmol/min/kg) |
|
|---|---|---|---|---|---|---|
| WT mice | 3 | 328 ± 41 | 135 ± 41 | 165 ± 61 | 12.4 | |
| +Cyclosporin A | 2 | 15 | 540 | 315 | 225 | 16.9 |
| +LY335979 | 3 | 15 | 626 ± 82 | 368 ± 30 | 259 ± 45 | 19.5 |
| +WK-X-34 | 3 | 15 | 674 ± 139 | 238 ± 63 | 437 ± 127 | 32.9 |
| +Cyclosoprin A | 3 | 30 | 1488 ± 146 | 829 ± 166 | 657 ± 38 | 49.4 |
| +LY335979 | 3 | 30 | 1407 ± 70 | 524 ± 58 | 883 ± 59 | 66.4 |
| +WK-X-34 | 3 | 30 | 2069 ± 204 | 757 ± 100 | 1311 ± 87 | 98.6 |
| mdr1a/1b KO mice | 3 | 1092 ± 118 | 245 ± 69 | 847 ± 144 | 63.7 |
Data are represented as mean ± S.D.