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. 2021 Mar 3;11(3):176. doi: 10.3390/jpm11030176

Table 2.

Findings of included studies.

Study Weight kg (Mean ± SD) BMI kg/m2 (Mean ± SD) Depression
Baseline Post p-Value Baseline Post p-Value Baseline Post p-Value
Bot et al. [30] P: 31.4
P + FRBA: 31.2
S: 31.3
S + FRBA: 31.7
P: 7.3 (4.1)
P + FRBA: 7.4 (4.4)
S: 7.9 (4.4)
S + FRBA: 7.1 (4)
Breymeyer et al. [28] HGL: 2.80
LGL: 2.03
p = 0.002
Brinkworth, Buckley et al. [31] LCHF: 96 ± 1.6
HCLF: 97.6 ± 1.6
LCHF: 82.3 ± 2.1 HCLF: 83.9 ± 1.9 BDI: p = 0.05
POMS: p = 0.05
Brinkworth, Luscombe-Marsh et al. [39] LC: 101.8 ± 2
HCLF: 101.1 ± 2
LC: 92.6 ± 2 HCLF: 91 ± 2
Canheta et al. [47] 46.3 ± 6.5 p < 0.001
Coates et al. [46] AED: 84.4 ± 12
NF: 85.4 ± 14
AED: 84.8 ± 1.38
NF: 85.6 ± 1.36
p > 0.05 AED: 30.2 ± 0.44
NF: 30.6 ± 0.43
AED: 30.5 ± 0.44
NF: 30.3 ± 0.43
p > 0.05 AED: 0.89 ± 1.9
NF: –3.74 ± 1.88
AED: 1.11 ± 2.2
NF: –2.22 ± 2.17
POMS: p > 0.05
Crerand et al. [43] D: 97.8 ± 13.5
C: 96.1 ± 12.1
D: 36.2 ± 4.5
C: 35.3 ± 4.3
D vs. C: p < 0.001 D: 7.7 ± 5.5
C: 7.4 ± 5.9
p < 0.001
Fuller et al. [40] D: 90.9 ± 12.2
C: 93.8 ± 12.7
D: –7.9 ± 2.1
C: 0.1
D: 34.1 ± 4.3
C: 35.2 ± 4.8
D: 22.1 ± 8.1
C: 23.7 ± 11.1
D: 19.3 ± 6
C: 25.3 ± 12.7
POMS: time x group p < 0.001
Galletly et al. [29] HPLC: 104.2 ± 5.3 LPHC: 98.6 ± 4.6 HPLC: –6.9 ± 0.8 LPHC: –8.5 ± 6.3 HPLC: 37.6 ± 6.4 LPHC: 37.2 ± 6.9 HPLC: 34.5 ± 5.7 LPHC: 34.5 ± 6.3 HPLC: 5.6 ± 3.2 LPHC: 4.8 ± 3.4 HPLC: 3.6 ± 2.8 LPHC: 3.4 ± 3.3 HPLC: p < 0.001
LPHC: NS
Hadi et al. [49] 89.4 ± 16.1 –5.2% ± 4.3% p < 0.001 31.1 ± 3.9 5 ± 4.6 2 ± 4.1 p < 0.001
Halyburton et al. [44] LCHF: 93.6 ± 2.1 HCLF: 97 ± 2.1
LCHF: 33.3 ± 0.6 HCLF: 33.8 ± 0.6
p < 0.001
Hariri et al. [33] Su: 84.3 ± 11.7
P: 79.3 ± 11.4
Su: 78.96 ± 10.84
P: 76.89 ± 11.35
p < 0.001 Su: 32.4 ± 3.73
P: 31.2 ± 3.87
S: 30.4 ± 3.55
P: 30.3 ± 3.89
p < 0.001 Su: 25.4 ± 9.42
P: 26.17 ± 11.21
Su: 25.4 ± 9.42
P: 26.17 ± 11.21
p < 0.001
Lutze et al. [41] HP: 100.5 ± 1.8
HC: 102.6 ± 1.8
HP: –12.3 ± 1.4
HC: –10.9 ± 1.4
HP: 23.4 ± 1.09
HC: 23.04 ± 1.05
HP: 20.77 ± 0.97 HC: 20.19 ± 0.94 POMS: p < 0.001
SF-36 subscales vitality and mental health: p < 0.001
Pedersen et al. [48] Median: 92.8
LED: p < 0.001 Median: 31.4
Raman et al. [34] CRT-O: 40.3 ± 7.8
C: 39.2 ± 7.4
CRT-O: 38.9 ± 7.6
C: 39.7 ± 8.4
CRT-O:19.1 ± 11.2
C: 13.3 ± 12.2
CRT-O: 4.5 ± 5.1
C: 15.4 ± 12.2
Rodriguez-Lozada et al. [32] 87.7 –8.6 p < 0.001 31.6 –3.1 p < 0.001 6.6 –2.7 p < 0.001
Ruusunen et al. [35] –3.14 ± 4.5 30.5 ± 3.4 –1.16 ± 1.74 I vs. C: p = 0.024 I: 6.8 ± 5.6 I: –0.9 ± 4.5 I: p = 0.03
Sanchez et al. [45] Pro: 95.1 ± 13.9 Pro: –5.3 ± 4.3 Pro: 33.8 ± 3.3 Pro: 4.4 ± 4.1 Pro: –1.5 ± 3 p < 0.05
Uemura et al. [36] I: 66.3 ± 8.74 I: 64.6 ± 8.07 p < 0.001 I: 27.8 ± 3.1 I: 27.1 ± 2.82 p < 0.001 I: 17.64 ± 13.58 I: 10.05 ± 7.4 p < 0.001
Tan et al. [50] D: 93.8
C: 93.1
D: 92.7
C: 94.4
D: p < 0.05 D: 29.4
C: 29.2
D: 5.0
C: 4.0
D: 4.0
C: 3.0
p < 0.05
Vaghef-Mehrabany et al. [25] For >1.9kg weight loss:
HDRS: 13.2
BDI: 19.5
For >1.9kg weight loss:
HDRS: 9.1
BDI: 14.7
For >1.9kg weight loss:
HDRS: p < 0.001
BDI: p = 0.006
Vigna et al. [37] HE: 33.1 ± 0.84
C: 33.4 ± 0.83
HE: 32.01 ± 0.82
C: 32.08 ± 0.88
HE: 48.8 ± 1.03 HE: 43.2 ± 2.38 HE: p < 0.05
Webber et al. [38] BWL: 99 ± 16.7
EBT: 101 ± 10.8
BWL: 36 ± 4.3
EBT: 37 ± 4.9
BWL: –1.3
EBT: –0.6
BWL: p < 0.001
EBT: p = 0.032
BWL vs. EBT:
p < 0.03
BWL: 7.5 ± 6.4
EBT: 10.4 ± 9.8
BWL: –2.9
EBT: –3.1
BWL: p = 0.012
EBT: p = 0.006
Wing et al. [42] 103.2 ± 16.9 VLCD: 14.6 ± 9.4
BD: 11.4 ± 7.2
VLCD: 5 ± 6.3
BD: 2.9 ± 2.8
VLCD: p < 0.001
BD: p < 0.001

Abbreviations: AED = almond-enriched diet, BD = balanced diet, BDI = Beck’s depression inventory, BDI-II = Beck’s Depression Inventory-2, BWL = behavioral weight loss, C = control, CES-D = center for epidemiologic studies depression scale, CRT-O = cognitive remediation therapy for obesity, D = diet, EBT = emotional brain training, FRBA = food-related behavioral activation, HCLF = high carbohydrate and low fat diet, HDRS = Hamilton depression rating scale, HE = H. erinaceus supplement, HGL = high glycemic index, HP = high protein diet, HPLC = high protein, low carbohydrate diet, I = intervention group, LCHF = low carbohydrate, high fat diet, LED = low energy diet, LGL = low glycemic index, LPHC = low protein, high carbohydrate diet, NF = nut-free diet, P = placebo, Pro = probiotic group, POMS = profile of mood states, S = supplements, Su = sumac supplement group, SD = standard deviation, SF-36 = short form health status survey, VLCD = very low calorie diet.