Table 1.
Radiation response parameters of panobinostat-treated Huh7 and Hep3B cells.
| Cell Line/Treatment | D37 (Gy) | SER37 (DMSO Versus Panobinostat) | RBE37 (X-ray Versus Proton) |
|---|---|---|---|
| Huh7 | |||
| X-ray, DMSO | 3.96 ± 0.21 | ||
| X-ray, panobinostat | 3.45 ± 0.30 | 1.15 ± 0.04 | |
| Proton, DMSO | 2.99 ± 0.12 | 1.33 ± 0.02 | |
| Proton, panobinostat | 2.41 ± 0.25 | 1.25 ± 0.08 | 1.44 ± 0.02 ** |
| Hep3B | |||
| X-ray, DMSO | 3.54 ± 0.30 | ||
| X-ray, panobinostat | 3.20 ± 0.32 | 1.11 ± 0.02 | |
| Proton, DMSO | 3.00 ± 0.21 | 1.18 ± 0.02 | |
| Proton, panobinostat | 2.47 ± 0.21 | 1.21 ± 0.02 ** | 1.30 ± 0.02 ** |
Data are mean ± S.D. The p-values were calculated by unpaired two-tailed Student’s t test. ** p < 0.01. D37, radiation dose at 37% cell survival; SER, sensitization enhancement ratio; RBE, relative biological effectiveness.