Table 2.
A number of miRNAs significantly changed their expression according to the mutational status of each oncogene. This table lists the number of these miRNAs in patients carrying oncogene mutations.
| Gene | Mutated/Total Patients | Number of Entities (Altered miRNAs) | Up | Down | miRNAs Targeting Mutated Oncogene |
|---|---|---|---|---|---|
| BRAF | 2/33 | 7 | 1 | 6 | 0 |
| EGFR | 9/33 | 1 | 0 | 1 | 0 |
| ERBB2 | 1/33 | - | - | - | - |
| ERBB4 | 1/33 | - | - | - | - |
| FGFR3 | 1/33 | - | - | - | - |
| KRAS | 10/33 | 13 | 13 | 0 | 2 (hsa-miR-15b-3p, hsa-miR-21-3p) |
| NOTCH1 | 3/33 | 1 | 1 | 0 | 0 |
| PIK3CA | 3/33 | 0 | 0 | 0 | 0 |
| PTEN | 2/33 | 0 | 0 | 0 | 0 |
| STK11 | 2/33 | 31 | 30 | 1 | 1 (hsa-miR-548aa) |
| TP53 | 10/33 | 4 | 4 | 0 | 1 (hsa-miR-205-3p) |