Table 5.
Clinical trials that investigated the diagnostic value of circulating miRNAs in lung cancer. Clinical trials registered at the US National Institutes of Health database (ClinicalTrials.gov) using the keywords “miRNA and lung cancer” (search results from 12 January 2021).
| Title of Study | Status | Completion Date | Enrollment | Analysis | Study Results | Pre-Clinical References |
|---|---|---|---|---|---|---|
| Plasma microRNA Profiling as First Line Screening Test for Lung Cancer Detection: A Prospective Study | Active, not recruiting | September 2021 | 4119 participants (healthy heavy smokers) | Pre-selected panel of 24 miRNAs in plasma | Study not completed | [31,114,115] |
| Addition of microRNA Blood Test to Lung Cancer Screening Low Dose CT | Active, not recruiting | August 30, 2020 | 479 participants undergoing LDCT (smokers) | Hummingbird Diagnostic´s microRNA test for lung cancer diagnosis in total blood | No results available | Not provided |
| MicroRNA Genetic Signature in NSCLC Egyptian Patients | † Completed | August 2016 | 40 participants (20 NSCLC, 10 nonsmokers, 10 smokers) | miRNA signature pattern in NSCLC Egyptian patients (by microarray) | † No results available | Not provided |
| Quantification of microRNAs in Diagnosis of Pulmonary Nodules | Completed | May 2019 | 103 participants (patients with nodules >5 mm and <30 mm in the lung parenchyma) | Pre-selected panel of 34 miRNAs | No results available | Not provided |
| Plasma miRNAs Predict Radiosensitivity of Different Fractionation Regimes in Palliative Radiotherapy for Advanced Non-small Cell Lung Cancer: Multicenter Controlled Study (RadimiR-01) | † Unknown | Last update posted: March 2017 | Estimated 240 participants (NSCLC) | Unspecified miRNAs in plasma | † No results available | Not provided |
| Association between VEGF-C and miRNA and Clinical Non-small Cell Lung Cancer and Esophagus Squamous Cell Carcinoma | † Unknown | Last update posted: Nov 2010 | Estimated 250 participants (NSCLC) | Unspecified miRNAs in unspecifies biological samples, probably serum | † No results available | Not provided |
LDCT: low-dose computed tomography; NSCLC: non-small-cell lung cancer; † Study has passed its completion date, and status has not been verified in more than two years.