Table 2.
Cox proportional-hazard regression analysis for survival and B-cell proportions estimated by CIBERSORTx and MuSiC (prop., proportion; HR, hazard ratio; CI, confidence interval; ref, reference).
| Variables | CIBERSORTx | MuSiC | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Cell type prop. | ||||||
| B-cell low (ref) | 1.00 | 1.00 | ||||
| B-cell high | 0.59 | 0.45–0.79 | 3 × 10−4 | 0.69 | 0.44–1.11 | 0.126 |
| Stage | ||||||
| Stage I (ref) | 1.00 | 1.00 | ||||
| Stage II | 1.57 | 0.60–4.08 | 0.353 | 1.67 | 0.64–4.34 | 0.293 |
| Stage III | 1.93 | 0.75–4.96 | 0.173 | 1.94 | 0.76–4.99 | 0.168 |
| Stage IVA | 2.71 | 1.11–6.65 | 0.029 | 2.72 | 1.11–6.66 | 0.029 |
| Stage IVB | 5.95 | 1.79–19.74 | 0.004 | 6.75 | 2.03–22.44 | 0.002 |
| Stage IVC | 27.77 | 3.03–254.86 | 0.003 | 21.37 | 2.34–194.94 | 0.007 |
| Not reported | 2.34 | 0.89–6.14 | 0.085 | 2.18 | 0.83–5.73 | 0.114 |
| Race | ||||||
| White (ref) | 1.00 | 1.00 | ||||
| Black | 1.57 | 0.97–2.55 | 0.069 | 1.46 | 0.9–2.37 | 0.127 |
| Hispanic | 1.54 | 0.86–2.78 | 0.15 | 1.52 | 0.84–2.74 | 0.163 |
| Other | 1.08 | 0.55–2.12 | 0.834 | 1.09 | 0.56–2.16 | 0.795 |
| Smoke | ||||||
| Never (ref) | 1.00 | 1.00 | ||||
| Ever | 0.85 | 0.61–1.19 | 0.343 | 0.88 | 0.63–1.22 | 0.432 |
| Age | 1.02 | 1.01–1.03 | 0.003 | 1.02 | 1.01–1.03 | 0.006 |