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. 2021 Mar 3;11(3):175. doi: 10.3390/jpm11030175

Figure 1.

Figure 1

Figure 1

Effect of the selected drug compounds on the response of NF-κB reporter cells to IL-1β ± dexamethasone (dex). In vitro validation of the top five drug compounds from the Connectivity Map analysis in the Childhood Asthma Management Program and Severe Asthma Research Program III: (a) γ-linolenic-acid, (b) ampicillin, (c) exemestane, (d) brinzolamide, and (e) INCA-6. The luciferase activities of reporter cells treated with the drug compounds were compared to that of untreated cells. Data represent means ± standard errors compared using t-tests. * p < 0.05 (drug compounds vs. untreated in cells exposed to IL-1β alone); # p < 0.05 (drug compounds vs. untreated in cells exposed to IL-1β ± dex).