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. 2021 Mar 11;11(3):162. doi: 10.3390/metabo11030162

Figure 3.

Figure 3

Boxplots of the biomarker metabolites measured in Day-0 plasma of Asturiana de los Valles recipients transferred with vitrified/warmed embryos (discovery study) as diagnosed at birth (i.e., Stearic Acid, ROC-AUC = 0.881 (0.571–1.000) (A), Palmitic Acid, ROC-AUC = 0.976 (0.786–1.000) (B), and 6-methyl-5-hepten-2-one, ROC-AUC = 0.833 (0.500–1.000) (C)), and in Day-7 plasma (Hippuric Acid, ROC-AUC = 0.857 (0.571–1.000) (D)), from open (blue boxes) and pregnant (yellow boxes). Black dots represent the concentrations of all samples of each metabolite scaled as Log Fold Change values. The notch indicates the 95% confidence interval around the median. The mean concentration of each group is shown by a red diamond. The optimal cut-off is indicated as a horizontal red line (i.e., the closest to the left-hand corner in the corresponding ROC-AUC). Frequency rankings by a Support Vector Machine (SVM) algorithm for top biomarkers, including those of the above boxplots, are shown on Day-0 plasma at birth (E), and on gestational days 40 and 62 (same biomarkers) (F) (1: Pregnant or birth to term recipients. 0: open recipients).