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. 2021 Mar 16;10(3):461. doi: 10.3390/antiox10030461

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Garcinol inhibited Lp(a)-induced activation of α7-nAChR/p38 MAPK/NFkB in cardiomyocyte AC16 cells. (A) Enzyme-linked immunosorbent assay (ELISA) result showed that garcinol significantly decreased the Lp(a)-induced expression of α7-nAChR and proinflammatory cytokines (interleukin-6 (IL-6), tumor necrosis factor (TNF)-α, C-reactive protein (CRP), and NFkB). (B) Protein and (C) mRNA expression of α7-nAChR, IL-6, TNF-α, CRP, and NFkB were significantly reduced by garcinol. * p < 0.05, ** p < 0.01, *** p < 0.001.