Table 2.
Residues common to three programs identified as participating in interface formation. Hotspot residues are in bold.
| CA | Residues |
|---|---|
| γ-PhCA | Interface AB |
| A: M1, A2, I4, K5, P6, Y7, N8, V25, I27, N41, V43, R45, D47, T63, I64, H66, H69, K70, N85, V86, M87, H89, T104, I105, M106, L122, S138 | |
| B: E22, N23, W39, Y40, N41, Q60, D61, G62, H84, N85, M101, S102, A119, T136, W153, N160, Y161, Y164, S167, Y168, Q171 | |
| Interface BC | |
| B: I4, K5, P6, Y7, N8, V25, I27, N41, V43, R45, D47, V48, G62, T63, I64, H66, D68, H69, K70, N85, V86, M87, H89, S102, T104, I105, M106, L122, S138 | |
| C: N23, W39, Y40, N41, Q60, D61, G62, H84, N85, M101, S102, A119, T136, W153, K156, N160, Y161, Y164, S167, Y168, Q171 | |
| Interface AC: | |
| A: N23, W39, Y40, N41, Q60, D61, H84, N85, M101, S102, A119, T136, N160, Y161, Y164, S167, Y168, N170, Q171 | |
| C: A2, I4, K5, Y7, N8, V25, I27, N41, V43, R45, D47, G62, T63, I64, H66, H69, V86, M87, H89, S102, T104, M106, D107, L122, S138 | |
| γ-PmCA | Interface AB |
| A: I3, I4, K5, P6, Y7, K8, Y11, N23, V25, I27, N41, V42, V43, R45, D47, V48, I64, H66, V67, D68, H69, N85, V86, M87, H89, A102, T104, M106, L122, S138 | |
| B: N23, W39, Y40, N41, Q60, D61, H84, N85, M101, S102, A119, T136, W153, N160, Y161, Y164, S167, Y168, N170, Q171, L172 | |
| Interface BC | |
| B: I3, I4, K5, P6, Y7, K8, V25, I27, N41, V43, R45, D47, V48, G62, T63, I64, H66, H69, N85, V86, M87, H89, S102, T104, V105, M106, L122, S138 | |
| C: N23, W39, Y40, N41, Q60, D61, H84, N85, M101, S102, A119, T136, N160, Y161, Y164, S167, Y168, N170, Q171, L172 | |
| Interface AC: | |
| A: E22, N23, W39, Y40, N41, D61, H84, N85, M101, S102, A119, G120, W153, N160, Y161, Y164, S167, Y168, Q171, L172 | |
| C: M1, A2, I3, I4, K5, P6, Y7, K8, V25, I27, N41, V43, R45, D47, G62, I64, H66, D68, H69, N85, M87, H89, S102, T104, V105, M106, L122 | |
| γ-TtCA | Interface AB |
| A: S2, V3, Y4, R5, F6, E7, K9, T10, Y24, V26, V42, R44, D46, L47, V63, H65, R83, V85, H87, G100, A101, V102, L104, V120, V136 | |
| B: W38, F39, Q59, D60, H82, R83, M99, A117, G118, V136, R152, Y153, L156, R159, Y160, A163, L164, F165, V167 | |
| Interface BC | |
| B: V3, Y4, R5, F6, E7, Y24, V26, V42, R44, D46, L47, V63, H65, R83, V85, H87, V102, L104, V120, V136 | |
| C: P21, G22, Y24, W38, F39, Q59, D60, H82, R83, M99, A117, G118, V136, R152, Y153, L156, R159, Y160, A163, L164, F165, P166, V167 | |
| Interface AC: | |
| A: P21, G22, W38, F39, Q59, D60, H82, R83, M99, A117, G118, L134, V136, R152, Y153, L156, R159, Y160, A163, L164, F165, P166, V167, A168, T169 | |
| C: M1, S2, V3, Y4, R5, F6, E7, T10, Y24, V26, V42, R44, D46, L47, V63, H65, D67, P68, R83, A84, V85, H87, G100, A101, V102, L104, V120, V136 | |
| γ-TtkCA | Interface AB |
| A: I2, Y4, K5, F22, I24, N38, T39, V40, R42, D44, V45, L59, T60, M61, H63, R82, A83, M84, H86, I101, L103, L119, S135, P136 | |
| B: E19, G20, W36, F37, N38, Q57, D58, L59, H81, R82, M98, G99, A116, G117, M133, H157, Y158, L161, Y165, D168 | |
| Interface BC | |
| B: Y4, K5, V7, F22, I24, N38, V40, R42, D44, V45, L59, T60, M61, H63, R82, M84, H86, I101, L103, L119, S135 | |
| C: E19, W36, F37, N38, Q57, D58, L59, H81, R82, M98, A116, G117, M133, H157, Y158, L161, Y165, D168 | |
| Interface AC: | |
| A: E19, G20, W36, F37, N38, Q57, D58, L59, H81, R82, M98, G99, A116, G117, H157, Y158, L161, Y165, D168 | |
| C: Y4, K5, G6, F22, I24, N38, V40, R42, D44, V45, L59, T60, M61, H63, R82, M84, H86, G99, I101, L103, L119, S135 |