Figure 2.

Volcano plots for global changes in genes and metabolites induced by gentamicin. Log₂ fold changes in gene expression induced by gentamicin compared with those induced by vehicle are plotted against the false discovery rates (FDRs), in kidney tissue after 7 (A) or 13 h (B) or in liver tissue after 7 (C) or 13 h (D). Red and green circles indicate significantly (FDR < 0.1) upregulated and downregulated genes, respectively. Black circles represent genes that did not change significantly. Log₂ fold changes in metabolite levels induced by gentamicin relative to those induced by vehicle in urine after 7 (E) or 13 h (F) or in plasma after 7 (G) or 13 h (H). Red and green circles indicate significantly (FDR < 0.1) increased and decreased metabolites, respectively. Black circles represent metabolites that did not change significantly. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)