. 2019 Nov 19;173(2):293–312. doi: 10.1093/toxsci/kfz228

Table 2.

List of Significantly Altered Metabolites in the Plasma Based on Model Predictions at 7 and 13 h Postgentamicin Exposure

Main Pathway	Subordinate Pathway	Metabolite	Log₂ (Fold Change)
Main Pathway	Subordinate Pathway	Metabolite	7 h	13 h
Metabolism of cofactors	Nicotinate and nicotinamide	Quinolinate	0.92
		N1-methyl-4-pyridone-5-carboxamide	0.58
		N1-methyl-2-pyridone-5-carboxamide	0.58
	Thiamine	Thiamine monophosphate	0.63
Carbohydrate metabolism	Ascorbate and aldarate	Inositol	0.57
	Pentose and glucuronate	Glucuronate	0.74
		Xylitol	0.59
		Ribitol	0.45
	Amino sugar and nucleotide sugar	Neu5Ac	0.72
	Amino sugar and nucleotide sugar	Neu5Gc	1.08
AA metabolism	Arginine and proline	Argininosuccinate	0.81
		Urea	1.39	1.10
		4-Acetamidobutanoate	0.77
	Lysine degradation	l-Pipecolate	0.57	0.54
	Cysteine and methionine	5-Methylthioadenosine	0.54
	Phenylalanine	2-Hydroxyphenylacetate	1.38
	Tryptophan	2,5-Dihydroxybenzoate	1.36
		Indoleacetate	0.91
		Xanthurenate	1.05
		Anthranilate	0.64
Nucleotide metabolism	Pyrimidine	Orotidine-5-phosphate	0.74
Nucleotide metabolism	Pyrimidine	Cytidine	−0.45