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. 2019 Nov 25;173(2):402–415. doi: 10.1093/toxsci/kfz235

Figure 9.

Figure 9.

Receiver operating characteristic curves were calculated for 4 models (model 1: includes relative APD90%, relative APD50%, relative triangulation, relative conduction velocity (CV), and arrhythmias at any concentration; model 2: includes relative APD90%, relative APD50%, relative triangulation, and relative CV; model 3: includes relative APD90%, relative APD50%, relative triangulation, and arrhythmias at any concentration; model 4: includes relative APD90%, relative APD50%, and relative triangulation). Inclusion of CV on prediction models increased the ability to discriminate between drugs classified as low risk for arrhythmogenesis in relation to those that are classified as high risk and intermediate/high risk for causing arrhythmias.