Table 3.

PARK2-mutated iPSC-derived neuronal phenotypes.

Reference	Number of Cohorts	Type of Mutation	Cell Type	Phenotype
[119]	6 PD patient lines vs. 3 control lines	Exon 2–4 or 6–7 deletions	iPSC-derived DA neurons	1. Increased Oxidative stress 2. Mitophagy impairment
[122]	3 PD patient lines vs. 3 control lines	Exon 3–5 or R42P deletions	iPSC-derived DA neurons	1. Dopamine dysregulation
[111]	2 PD patient lines vs. 2 control lines	Exon 2–4 or Exon 6–7 deletions	iPSC-derived DA neurons	1. Increased oxidative stress 2. Mitochondrial dysfunction 3. Increase α-synuclein aggregation
[123]	4 PD patient lines with 1 control line	Exon 3–4, R275W or R42P deletions	iPSC-derived DA neurons	1. Mitochondrial dysfunction 2. Increase α-synuclein aggregation
[124]	1 PD patient line vs. 1 control line	Del202-203AG and IVS1+1G/A	iPSC-derived DA neurons	1. Increased cell death
[113]	2 Isogenic mutated PD lines vs. 1 control line	Exon 2 deletion	iPSC-derived DA neurons	1. Mitochondrial dysfunction
[118]	2 PD lines vs. 2 control lines	Exon 4 deletion	iPSC-derived DA neurons	1. Dopamine dysregulation 2. Increased oxidative stress
[125]	2 PD lines vs. 2 control lines	Exon 2–4 deletion	iPSC-derived DA neurons	1. Mitochondrial dysfunction
[126]	2 Isogenic mutated iPSC lines vs. 1 control line	Exon 2 deletion	iPSC-derived DA neurons	1. Lysosomal dysfunction
[120]	1 PD line vs. 1 control line	Exon 5 deletion	iPSC-derived DA neurons	1. Increase α-synuclein aggregation 2. Reduced level of anti-oxidative proteins
[127]	3 PD lines vs. 3 control lines	Exon 7 deletion, c.1072delT or Exon 1 deletion and c.924C>Tor c.1072delT	iPSC-derived DA neurons	1. Mitochondrial dysfunction
[112]	2 PD lines vs. 2 control lines	c.1366C.T and c.1072Tdel	iPSC-derived DA neurons	1. Dopamine dysregulation 2. Increase cell death 3. Increase α-synuclein aggregation