Table 4.

PINK1-mutated iPSC-derived neuronal phenotypes.

Reference	Number of Cohorts	Type of Mutation	Cell Type	Phenotype
[137]	3 PD lines vs. 1 control line	c.1366C>T, c.509T>G	iPSC-derived DA neurons	1. Mitochondrial dysfunction
[84]	5 PD lines vs. 2 control lines	Q456X, R1441C	iPSC-derived DA neurons	1. Increase in oxidative stress 2. Mitochondrial dysfunction
[141]	1 PD line vs. 1 control line	V170G	iPSC-derived DA neurons	1. Impairement in mitophagy
[140]	7 PD lines vs. 5 control lines	Exon 4 or 7 deletion	iPSC-derived DA neurons	1. Dysregulation of LRKK2 levels 2. Mitochondrial dysfunction