Table 4.

Reports regarding the derivation of HT claimed for food application: esters and polyacrylates.

Application	Results	Ref.
Virgin olive oil	↑ oxidation preventive action with HT.	[94]
Claim for Food application	The protective effects against DNA damage of HT esters were inversely proportional to their chain length.	[86]
Food application	Antioxidant capacity of HT esters > TYR esters. ↓capacity in lipophilic food matrices.	[93]
Functional foods	HT octanoate (C8) is the most effective to inhibit the oxidation in fish O/W.	[95]
Claim for food application	↓ antioxidant activity of HT esters with alkyl chain length around C8–C11 in different matrices	[96]
Claim for application	↓ Antioxidant function of HT esters with chain lengths > C10, measured through ABTS (in ethanol medium) and DCF (on cultured muscle cells).	[97]
Claim for food application	HT esters were produced by enzymatic transesterification with cuphea oil. HT esters antioxidant activity ≈ HT decanoate (C10).	[98]
Therapeutic strategy	Antioxidant capacity of HT laurate (C12) > HT against H2O2 induced apoptosis in U937cells and C2C12 murine myoblasts.	[99]
Claim for food application	Antioxidant activity of all the HT, with exception of HT stearate (C18), >HT C10 esters in human erythrocytes. C12 were optimum in scavenging free radicals.	[100]
Claim for food application	HT esters were able to scavenge DPPH radical, render inhibitory effects on cupric ion-induced LDL oxidation and show protective effects against hydroxy radical- and peroxy radical-induced DNA scission.	[101]
Claim for food packaging application)	PHTA (up to 50 mg/mL) fully scavenged DPPH free radicals. No cytotoxic activities from polyacrylates films in RAT1 normal fibroblast cells were observed for concentrations of 0.25–1 mg/mL of polyacrylate film	[102]

ABTS—2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid); DCF—Dichlorodihydrofluorescein fluorometric assay; DPPH—α-Diphenyl-β-picrylhydrazyl; DNA—Deoxyribonucleic acid; HT—Hydroxytyrosol; H₂O_2—Hydrogen peroxide; LDL—Low Density Lipoprotein; O/W—Oil-in-water emulsion; PHTA—Poly(hydroxytyrosyl)acrylate; TYR—Tyrosol.