Table 2.
Mean percentages of immune cell populations with the relative statistical significance of differences between groups.
| Immune Subset | Controls N = 10 |
CP Donors Eight Months N = 47 |
CP Donors Two Months N = 47 |
p Value ** | p Value *** |
|---|---|---|---|---|---|
| Lymphocytes (% of WBCs) |
31.41 ± 7.78 * | 36.95 ± 8.74 | 32.96 ± 8.57 | ns | 0.002 |
| CD3+ T Cells (% of Lymphocytes) |
67.07 ± 8.61 | 71.51 ± 6.80 | 72.70 ± 6.50 | ns | ns |
| CD8+ T Cells (% of CD3+ T Cells) |
24.38 ± 8.51 | 32.65 ± 9.37 | 33.38 ± 10.38 | 0.013 | ns |
| CD4+ T Cells (% of CD3+ T Cells) |
71.36 ± 11.28 | 61.40 ± 10.12 | 60.43 ± 10.82 | 0.008 | ns |
| CD8+ Tregs (% of CD8+ T Cells) |
7.29 ± 8.24 | 2.67 ± 3.74 | 3.86 ± 4.95 | 0.011 | ns |
| CD4+ Tregs (% of CD4+ T Cells) |
2.04 ± 0.90 | 1.48 ± 0.90 | 1.87 ± 1.28 | ns | <0.001 |
| Th1 (% of CD4+ T Cells) |
26.77 ± 7.96 | 32.71 ± 10.35 | 29.25 ± 10.32 | ns | 0.022 |
| Th2 (% of CD4+ T Cells) |
7.67 ± 3.60 | 8.13 ± 9.11 | 8.86 ± 14.71 | ns | ns |
| Th17 (% of CD4+ T Cells) |
1.73 ± 0.96 | 1.09 ± 1.79 | 2.61 ± 6.63 | ns | ns |
| Th9 (% of CD4+ T Cells) |
11.57 ± 4.10 | 6.45 ± 6.01 | 16.15 ± 16.74 | 0.013 | <0.001 |
| B Cells (% of Lymphocytes) |
18.74 ± 5.60 | 12.74 ± 4.39 | 13.13 ± 5.59 | <0.001 | ns |
| NK Cells (% of Lymphocytes) |
12.14 ± 6.13 | 13.41 ± 6.43 | 12.43 ± 5.42 | ns | ns |
| Immature NK Cells (% of NK Cells) |
0.69 ± 0.32 | 0.71 ± 0.63 | 0.72 ± 0.63 | ns | ns |
| Mature NK Cells (% of NK Cells) |
8.84 ± 5.05 | 10.33 ± 5.53 | 8.55 ± 4.84 | ns | 0.001 |
| Memory-like NK Cells (% of NK Cells) |
2.61 ± 1.20 | 2.37 ± 1.48 | 3.16 ± 1.81 | ns | 0.007 |
| CD3+CD56−CD16+ NKT Cells (% of CD3+ Cells) |
0.19 ± 0.13 | 0.07 ± 0.15 | 0.25 ± 0.47 | 0.029 | 0.014 |
| CD3+CD56+CD16− NKT Cells (% of CD3+ Cells) |
1.80 ± 2.05 | 7.07 ± 6.13 | 6.00 ± 5.29 | 0.010 | 0.002 |
| Monocytes (% of WBCs) |
3.52 ± 0.66 | 5.11 ± 1.20 | 3.84 ± 1.34 | <0.001 | <0.001 |
| Classical Monocytes (% of Monocytes) |
95.04 ± 3.14 | 97.57 ± 2.13 | 91.95 ± 12.22 | 0.003 | <0.001 |
| Intermediate Monocytes (% of Monocytes) |
0.81 ± 0.64 | 0.89 ± 1.14 | 0.99 ± 1.21 | ns | ns |
| Non-classical Monocytes (% of Monocytes) |
0.27 ± 0.24 | 0.27 ± 0.54 | 1.16 ± 2.45 | ns | 0.012 |
| Granulocytes (% of WBCs) |
56.84 ± 8.56 | 49.86 ± 7.80 | 53.20 ± 7.88 | 0.014 | 0.002 |
| CD11b+ Granulocytes (% of Granulocytes) |
46.12 ± 34.14 | 50.94 ± 23.16 | 64.52 ± 25.10 | ns | 0.001 |
| CD11b− Granulocytes (% of Granulocytes) |
47.29 ± 27.52 | 41.43 ± 18.13 | 27.38 ± 18.47 | ns | <0.001 |
* mean percentage ± standard deviation; ** statistical significance of controls vs. CP donors at eight months (Student’s t-test); *** statistical significance of CP donors at eight months vs. CP donors at two months (paired Student’s t-test); ns, non-significant.