Figure 7.
Clustering analysis plot of fibroblasts (F) and derived ELC showing marked changes in pattern-gene expression, with downregulation of canonical TGF-β and Wnt pathways in the ELC derived from fibroblasts. Cluster analysis of fibroblasts and derived ELC. Upregulated and downregulated genes are represented in red and green colors, respectively (A). Pathway analysis was performed using ingenuity pathway analysis (IPA) software, as described in the Methods. Transcription factors Snail, Twist, and Zeb were downregulated (green), while E-cadherin was upregulated (B).
