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. 2021 Mar 18;118(12):e2013239118. doi: 10.1073/pnas.2013239118

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Fig. 7. — The Wnt target genes eva-1/EVA1C and rga-9b/ARHGAP are up-regulated during QR lineage progression and required for terminating the anterior migration of the final QR descendants. (A) A schematic representation of the QR lineage and the role of canonical Wnt signaling (BAR-1) in stopping the migration of QR.pa. (B) The normalized RNA-seq expression levels in populations enriched for early (Q) and late (Q.pa and Q.ap, [Q.xx]) Q descendants in mab-5(gk670). The bars represent mean ± SEM. (C) Fold change in expression of genes differentially expressed in ΔN-BAR-1 (FDR < 0.1) compared to fold change in expression between populations enriched for Q and Q.xx. (D) The position of the final QR.p descendants QR.paa and QR.pap (QR.pax) with respect to seam cell nuclei, indicated as percentiles of the total number of cells analyzed (n > 50 for all genotypes). The statistical significance (compared to wild type) was calculated using Fisher’s exact test (**P < 0.01, ***P < 0.001, and ****P < 0.0001). (E) A model of cross-talk between noncanonical and canonical Wnt/BAR-1 signaling in QR descendant migration.