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Next-generation LOH targeting. (A) NASCAR targeting as applied to genetically unlinked molecules. (B) NASCAR targeting as applied to intracellular polymorphic peptides that are presented on the cell surface in the context of HLA molecules. (C–E) A model of tumor-specific inhibitory markers revealed by LOH that are amenable to NASCAR-based targeting. (F) TAA-specific synNotch receptor-driven conditional expression of a NASCAR expression cassette. TF, transcription factor.
