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. 2021 Mar 15;118(12):e2024865118. doi: 10.1073/pnas.2024865118

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Fig. 1. — CRTC is required for starvation resistance. (A) UCSC genome browser view showing loss of Crtc transcripts in Crtc KO flies. (B) Western blot showing Crtc protein amounts in wild-type and Crtc KO flies. (C) Survival rates of w1118 control and Crtc KO flies after 24-h and 40-h fasting. (D) Comparison of lifespan at ambient temperature. Blue curve, wild-type flies. Yellow curve, Crtc KO flies. (E) Climbing assay showing mobility of Crtc KO flies relative to Crtc heterozygous flies and wild-type control flies. (F) Effect of 31 °C thermal stress on survival of Crtc KO compared to wild-type flies. ***P < 0.001; ****P < 0.0001; n.s., not statistically significant.