Table 1.
Summary of retinal neuroprotection studies that use zebrafish retinal injury paradigms.
| Retinal Injury Paradigm | Model | Age | Neuroprotective Agent or Mechanism | Reference |
|---|---|---|---|---|
| Light-Induced | ||||
| LIRD | Retinal degeneration | Larvae | EP300 (Histone acetyltransferase) | [164] |
| LIRD and ouabain | Retinal degeneration | Adult | SHH-N recombinant protein | [169] |
| Rose Bengal Light lesion | Retinal degeneration | Adult | Thiokynurenate (NMDA inhibitor) | [160] |
| Mechanical | ||||
| Optic nerve injury | RGC loss/injury | - | Neuroglobin | [195] |
| Chemical-Induced | ||||
| NMDA-induced neurodegeneration | Retinal degeneration | Adult | Resveratrol and MK-801 | [180] |
| Glaucoma | Adults | Resveratrol | [185] | |
| Acrylamide toxicity | Retinal Toxicity | Embryo | Carnosic acid | [176] |
| 6-OHDA | Night blindness | Larvae/adult | Stil-mediated Shh signaling | [179] |
| Oxidative Stress | ||||
| Hypoxia/reperfusion | Retinal degeneration | Embryo | HSF1 | [198] |
| Hypoxia | Hypoxia-driven retinal angiogenesis | Adult | Sunitinib and ZN323881 (anti-VEGF drugs) | [199] |
| Hydrogen peroxide | RGC degeneration | Larvae | Neurotrophins-magnetic nanoparticles | [200] |
| Paclobutrazol | Hypoxia | Embryo | Retinoic Acid | [186] |
| Age | Age-related oculopathy | Adult | Resveratrol | [201] |
| Diet-Induced | ||||
| MeHg-diet exposure | Retinal Toxicity | Embryo | Selenium | [95] |
| Genetically Targeted | ||||
| von Hippel-Lindau mutants | Vascular-driven retinopathies | Embryo | Sunitinib and 676475 | [202] |
| Gdf6 zebrafish mutants | Early onset retinal dystrophies | Embryo | Aminopropyl Carbazole, P7C3 | [203] |
| AMD, Tg(rho:hsa.HTRA1); RP, Tg(rho:hsa.RHO_Q344ter) | AMD and RP | Larvae | 6-boroV (HTRA1 inhibitor) | [204] |
| Tg line dyeucd6 | RP | Larvae | Tubastatin A (TST) | [205] |
Abbreviations: LIRD, light-induced retinal degeneration; HSF, Heat shock factor; Shh, Sonic hedgehog; RGC, retinal ganglion cells; MeHg, Methylmercury; SeMet, selenomethionine; 6-OHDA, 6-hydroxy-dopmine; HTRA1, High-Temperature Requirement A 1; RP, retinitis pigmentosa; AMD, age-related macular degeneration.