Figure 3.

Pathways and processes modulated by disordered driver mutations. (A) Overrepresentation of molecular toolkits defined based on gene ontology (GO) terms for ordered (blue) and disordered (red) drivers, compared to the average of the whole human proteome. Categories enriched in disordered drivers represented in bold. B-D: schematic examples of receptor tyrosine kinases (RTKs) (B), transcription factors (C) and components of the ubiquitin ligase machinery (D) that are modulated through disordered driver regions. Typically, these proteins have a modular architecture. Functional modules that are mutated preferentially in disordered or ordered regions are placed above or below the middle line.