Figure 5.

Therapeutic options for targeting disordered drivers. (A) Fraction of samples that contain altered driver genes per cancer type. Samples can contain mutations affecting only ordered drivers (blue), only disordered drivers (red) or both (mixed, gray). (B) Percentage of cancer samples, grouped by cancer types, containing genetic alterations that target the identified disordered driver regions. (C) The distribution of disordered drivers from the three classes of cancer genes (oncogenes, tumor suppressor genes (TSG) and context dependent genes) categorized into specific, narrow and broad range based on the frequency of samples they are mutated in (see Data and Methods). (D) The probability of having an available FDA-approved drug for at least one mutation-affected gene for patients, as a function of the ratio of affected disordered genes compared to all mutated genes in the sample. The horizontal black line represents the total fraction of targetable samples (0.49) from 8444 samples.