Table 1.
Summary of in vitro and in vivo investigations with main results.
| Article | Type of Study | Probiotic Strain | Aim of Study | Main Results |
|---|---|---|---|---|
| Olson et al. 2016 [41] | In vivo | L. reuteri ATCC 23272 | To evaluate the efficacy of a novel probiotic delivery system in an experimental model of necrotizing enterocolitis | A single dose of L. reuteri in its biofilm state significantly decreased:
|
| Navarro et al. 2017 [40] | In vitro | L. reuteri ATCC 23272 | To evaluate the effect of enhancing a novel L. reuteri biofilm formulation with the addition of beneficial compounds as diffusible cargo within DMs | An enhanced probiotic formulation resulted in increased:
|
| Olson et al. 2018 [69] | In vivo | L. reuteri ATCC 23272 | To evaluate the efficacy of an enhanced novel L. reuteri biofilm formulation with beneficial cargo on protection from experimental NEC | A single dose of enhanced L. reuteri biofilm formulation with beneficial DM cargo resulted in decreased:
|