Table 6.
List of top eight upstream regulators obtained by IPA analysis of differentially expressed proteins in hill extract treated SH-SY5Y cells.
| Upstream Regulator | Molecule Type | Activation z-Score | p-Value of Overlap | Target Molecules |
|---|---|---|---|---|
| TP53 | Transcription regulator | 0.295 | 8.48 × 10−11 | ACADVL, ACTB, ADH5, ANXA2, CS, EZR, GC, GSN, HNRNPA2B1, HSPA1A/HSPA1B, HSPA8, NARS1, PDCD6IP, PFKM, PGM3, PKM, PSMA2, PSMD2, RAP2A, SLC25A13, UBQLN2, VCL, VIM, XRCC5 |
| MAPT | Other | 7.74 × 10−9 | ACTB, ACTG1, CS, DPYSL2, DPYSL3, EEF2, HSPA1A/HSPA1B, HSPA5, HSPA8, PKM, PSMD2 | |
| BDNF | Growth factor | 0.29 | 2.53 × 10−7 | ANXA2, DPYSL3, EEF1D, EEF2, FLNA, HSPA5, RNH1, VGF, VIM |
| IL5 | Cytokine | 2.236 | 1.25 × 10−3 | ANXA2, HSPA5, LMNB1, PKM, VIM |
| SP1 | Transcription regulator | 2.211 | 5.07 × 10−3 | ADH5, EZR, FLNA, HSPA5, PKM, VIM |
| FGF2 | Growth factor | 2.391 | 1.1 × 10−3 | FLNA, LMNA, SCG2, VGF, VIM, XRCC5 |
| RET | Kinase | 2.186 | 1.6 × 10−5 | DPYSL2, HSPA1A/HSPA1B, HSPA8, UBQLN2, VGF |
| MYC | Transcription regulator | 2.185 | 1.32 × 10−5 | ACTB, EEF2, EIF2S1, EZR, FLNA, HNRNPA2B1, HNRNPD, NARS1, PFKM, PKM, POLR2G, VDAC2, VIM |