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. 2021 Mar 8;10(3):270. doi: 10.3390/antibiotics10030270

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A). LCMS analysis of vancomycin in effluent samples from antibiotic loaded calcium sulfate beads with an antibiotic loaded PMMA spacer (CSB_v+tplusSpacer_v+t), antibiotic loaded PMMA spacer (Spacer_v+t), and vancomycin powder bolus (VP). N = 9; geometric mean ±SE. The yellow curve is the influent saline flow rate. Time is shown on a log2 scale to more clearly show the changes in concentration at the early time points. (B). Log difference of vancomycin effluent concentrations of the CSB_v+tplusSpacer_v+t compared to the Spacer_v+t alone. (* p < 0.05, ** p < 0.01).