Table 3.

AUC values in the extended multivariate models for the probability of macrosomia.

	Macrosomia (>4000 g)
Base Model (Maternal Age + Parity c **)	0.564	Base Model (0.501–0.627)	0.04	Differences *
Extended Models (Base Model + Listed Variables)	AUC	±95%CI	p-Value	AUC Difference	±95%CI	p ***
Pre-pregnancy weight (kg)	0.706	(0.649–0.764)	<0.001	0.142	(0.077–0.208)	<0.001
Pre-pregnancy BMI (kg/m2)	0.671	(0.611–0.731)	<0.001	0.107	(0.045–0.17)	0.001
BMI (c.)	0.666	(0.607–0.724)	<0.001	0.102	(0.039–0.164)	0.001
GWG above the range	0.656	(0.597–0.716)	<0.001	0.092	(0.03–0.155)	0.004
BMI ≥ 25 kg/m2	0.653	(0.593–0.713)	<0.001	0.089	(0.029–0.149)	0.003
Maternal height (cm)	0.651	(0.595–0.707)	<0.001	0.087	(0.024–0.15)	0.007
Fetal sex: Son	0.626	(0.566–0.687)	<0.001	0.062	(0.007–0.118)	0.028
Maternal height > 170 cm	0.618	(0.556–0.679)	<0.001	0.054	(0–0.109)	0.055
BMI ≥ 30 kg/m2	0.612	(0.547–0.678)	<0.001	0.048	(0.007–0.089)	0.022
Prior macrosomia	0.611	(0.547–0.674)	<0.001	0.047	(0.009–0.084)	0.014
Gestational age ≥ 38 weeks	0.602	(0.543–0.662)	0.001	0.038	(0.01–0.066)	0.008
Maternal height > 160	0.602	(0.544–0.659)	0.001	0.038	(0–0.079)	0.077
Family: diabetes in the mother	0.588	(0.528–0.648)	0.005	0.024	(0–0.064)	0.238
Interpregnancy interval (c.)	0.588	(0.527–0.648)	0.005	0.024	(0–0.06)	0.2
Family: diabetes in the father	0.584	(0.523–0.644)	0.007	0.020	(0–0.057)	0.29
Ex–smoking	0.576	(0.515–0.637)	0.015	0.012	(0–0.034)	0.282
GDM	0.573	(0.511–0.636)	0.019	0.009	(0–0.039)	0.538
Prior diabetes	0.571	(0.509–0.634)	0.022	0.007	(0.002–0.012)	0.005
Lower financial status	0.571	(0.509–0.632)	0.023	0.007	(0–0.024)	0.439
Folic acid supplementation	0.570	(0.508–0.632)	0.025	0.006	(0–0.04)	0.724
Education < 12 years	0.57	(0.507–0.633)	0.024	0.006	(0–0.022)	0.432
Marital status: married	0.569	(0.507–0.631)	0.027	0.005	(0–0.024)	0.602
Prior cesarean section	0.568	(0.505–0.631)	0.029	0.004	(0–0.022)	0.666
Village	0.568	(0.504–0.633)	0.028	0.004	(0–0.029)	0.728
Multivitamin supplementation	0.567	(0.504–0.629)	0.032	0.003	(0–0.019)	0.728
Never smoking	0.564	(0.501–0.627)	0.04	0.000	(0–0.006)	0.998

AUC: area under receiver operating characteristic curve; 95%CI: confidence intervals; * Differences between extended models and base model; ** parity (c) categories: 0, 1, 2 and ≥3 deliveries); *** p-Value < 0.05 was statistically significant. Macrosomia: birth weight > 4000 g (analysis for 97 cases vs. 755 newborns 2500–4000 g); BMI: body mass index; GWG: gestational weight gain; GDM: gestational diabetes mellitus.