Table 2. Hazard ratios of renal function decline according to changes of serum uric acid.

Types		Quartile1 (<-91.00) (n = 374)	Quartile2 (−91.00—36.68) (n = 371)	Quartile3 (−36.68–12.34) (n = 373)	Quartile4 (≥12.34) (n = 371)	P
Renal function reduction	Model 1	0.52 (0.39–0.69)	0.62 (0.48–0.80)	0.72 (0.56–0.92)	1.00	<0.001
	Model 2	0.53 (0.40–0.69)	0.62 (0.48–0.81)	0.73 (0.56–0.93)	1.00	<0.001
	Model 3	0.56 (0.42–0.73)	0.65 (0.50–0.84)	0.74 (0.58–0.95)	1.00	<0.001
	Model 4	0.55 (0.42–0.73)	0.66 (0.50–0.85)	0.75 (0.58–0.96)	1.00	0.002
	Model 5	0.64 (0.49–0.85)	0.65 (0.50–0.84)	0.75 (0.58–0.96)	1.00	<0.001

Notes.

Data are hazard ratio (95% confidence interval). Participants without renal function reduction are defined as 0 and with renal function reduction as 1. n, cases.

Model 1 is unadjusted.

Model 2 is adjusted for sex and age.

Model 3 is adjusted for sex, age and dietary exercise intervention.

Model 4 is adjusted for sex, age, dietary exercise intervention, Waist-to-Hip Ratio and BMI.

Model 5 is adjusted for sex, age, dietary exercise intervention, Waist-to-Hip Ratio, BMI, pulse pressure variation, 2hPG variation, AST variation, ALT variation, TC variation.

Body mass index (BMI, Kg/m2); 2 hour plasma glucose (2hPG, mmol/L); alanine aminotransferase (ALT, U/L); aspartate aminotransferase (AST, U/L); total cholesterol (TC, mmol/L).