Figure 1.

A schematic cell-to-cell spreading model of the dengue virus ingested in accompany with the blood meal in the mosquito midgut. (A) The virus infection in the female mosquito vector begins with a blood meal from viremia of a patient. (B) Simulation for cell-to-cell spread of the virus in the midgut of an engorged female. At the beginning, the ingested virus sporadically infects epithelial cells of the midgut. It is followed by extensively spread via cell-to-cell transmission before the virus disseminates to other organs.