Table 1.

miRNA expression in CVD patients, their function in the pathology of CVDs, and their potential target genes involved in ROS level regulation.

	Expression Levels in CVD Patients	Function in CVDs	Target Genes
miR-155	Up [71,72] Down [73,74]	Pathogenic	eNOS SIRT1
miR-15/16	Up [75] Down [76]	Controversial	eNOS SIRT1 (possible)
miR-221/222	Up [40,77,78,79] Down [80,81]	Protective	eNOS SOD2
miR-21	Up [45,77,81,82,83,84]	Controversial	eNOS SOD2
miR-199a	Up [44,85] Down [86]	Controversial	SIRT1 SOD1 eNOS (indirectly)
miR-34a	Up [39,45,84,87,88]	Pathogenic	SIRT1
miR-145	Down [46,89]	Protective	SIRT1
miR-210	Up [41,45,81,90,91]	Controversial	SIRT1
miR-126	Down [44,74,92,93]	Protective	SOD SIRT1 (possible)