Acronyms
ARDS	Acute respiratory distress syndrome
BGA	Blood gas analyzer
CFD	Computational fluid dynamics
CO2	Carbon dioxide
ECMO	Extracorporeal membrane oxygeantor
NDIR	Non-dispersive infrared photometer
HCO3−	Bicarbonate
LPV	Lung protective ventilation
N2	Nitrogen
O2	Oxygen
PBS	Phosphate buffered solution
SCC	Spearman correlation coefficient
PMP	Polymethylpentene
STP	Standard temperature and pressure (273.15 K, 1 bar)
RBC	Red Blood Cells
Latin Symbols
cCO2	Concentration of dissolved CO2
cCO2,pl	CO2 concentration in blood plasma
cCO2,rbc	CO2 concentration in red blood cells
cCO2,total	Total CO2 content of blood
cHCO3−	Bicarbonate concentration
ctHb	Hemoglobin concentration in whole blood
ctHb,rbc	Hemoglobin concentration in red blood cells (Siggaard-Anderson model)
Hbrbc	Hemoglobin concentration in red blood cells (Zierenberg model)
Hct	Measured hematocrit
K1	Equilibrium constant for the overall CO2 hydration reaction
kH	Henry coefficient for CO2 in water
Ks	Henry coefficient for the CO2 solubility in blood (May Model)
MCO2	Molar mass of CO2
pCO2	CO2 partial pressure
pHpl	pH in plasma
pHrbc	pH in red blood cells
pK	Negative logarithmic equilibrium constant for the overall CO2 hydration reaction
pKpl	Negative logarithmic equilibrium constant for the overall CO2 hydration reaction in blood plasma
pKrbc	Negative logarithmic equilibrium constant for the overall CO2 hydration reaction within RBC
Q	Empirical parameter of the Loeppky model
Qblood	Blood flow rate
QCO2,blood	CO2 removal determined with the blood-based prediction method
QCO2,sweep	CO2 removal determined with the sweep flow-based prediction method
QCO2,sweep,error	Error of the sweep flow-based CO2 removal prediction
q	Empirical parameter of the Loeppky model (multiplier)
Qsweep	Sweep flow rate
Rrbc	Donnan ratio for electrochemical equilibrium across the red blood cell membrane
SHbCO2	CO2 saturation of hemoglobin
SO2	Oxygen saturation
T	Temperature
t	Empirical parameter of the Loeppky model (exponent)
VM	Molar volume of CO2 at standard temperature and pressure
x, y	Arbitrary variable
Greek Symbols
αCO2	Solubility coefficient of CO2 in blood
αCO2,pl	Solubility coefficient of CO2 in blood plasma (Siggaard-Anderson model)
αCO2,rbc	Solubility coefficient of CO2 in red blood cells (Siggaard-Anderson model)
βCO2,pl	Solubility coefficient of CO2 in blood plasma (Zierenberg model)
βCO2,rbc	Solubility coefficient of CO2 in red blood cells (Zierenberg model)
ΔcCO2,blood	CO2 concentration difference between inlet and outlet on the blood side
ΔcCO2,sweep	CO2 concentration difference between inlet and outlet on the sweep fluid side
ΔpCO2	Drop of CO2 partial pressure over the membrane module
ΔcHCO3−	Drop of bicarbonate concentration over the membrane module
ΔpH	Increase of pH over the membrane module
ε	Relative deviation of blood-based from sweep flow-based CO2 removal prediction
$\overline{\mathsf{\epsilon }}$	Average relative deviation of blood-based from sweep flow-based CO2 removal prediction
ρCO2	Density of CO2 at standard temperature and pressure
ρwater	Density of water at 310.15 K
ϕ	Estimated hematocrit