Table A1.
Combinations of top prediction models and their diagnostic performance in Train and CV set.
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|---|---|---|---|---|---|---|---|
| Number of Variables | Model | Train Set | Cross-Validation (CV) Set | ||||
| Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | ||
| 0 | class~age + sex | 0.311 | 0.846 | 0.598 | 0.206 | 0.846 | 0.531 |
| 1 | class~age + sex + p16 | 0.944 | 0.846 | 0.953 | 0.839 | 0.846 | 0.886 |
| 2 | class~age + sex + p16 + p6 | 1.000 | 0.846 | 0.966 | 1.000 | 0.846 | 0.962 |
| 3 | class~age + sex + p16 + p6 + p2 | 1.000 | 0.846 | 1.000 | 0.783 | 0.885 | 0.863 |
| 4 | class~age + sex + p16 + p6 + p2 + p11 | 1.000 | 0.846 | 1.000 | 0.833 | 0.885 | 0.897 |
| 5 | class~age + sex + p16 + p6 + p2 + p11 + p19 | 1.000 | 0.846 | 1.000 | 0.733 | 0.846 | 0.855 |
| 6 | class~age + sex + p16 + p6 + p2 + p11 + p19 + p18 | 1.000 | 0.846 | 1.000 | 0.400 | 0.923 | 0.844 |
| 7 | class~age + sex + p16 + p20 + p6 + p2 + p11 + p19 + p18 | 1.000 | 0.846 | 1.000 | 0.400 | 0.923 | 0.867 |
| 8 | class~age + sex + p16 + p20 + p6 + p2 + p13 + p11 + p19 + p18 | 1.000 | 0.846 | 1.000 | 0.578 | 0.846 | 0.833 |
| 9 | class~age + sex + p16 + p20 + p6 + p2 + p13 + p11 + p15 + p19 + p18 | 1.000 | 0.846 | 1.000 | 0.200 | 0.923 | 0.797 |
| 10 | class~age + sex + p16 + p20 + p6 + p9 + p2 + p13 + p11 + p15 + p19 + p18 | 1.000 | 0.846 | 1.000 | 0.222 | 0.923 | 0.616 |
| 11 | class~age + sex + p16 + p20 + p6 + p9 + p22 + p2 + p13 + p11 + p15 + p19 + p18 | 1.000 | 0.846 | 1.000 | 0.100 | 0.923 | 0.658 |
| 12 | class~age + sex + p16 + p20 + p6 + p9 + p22 + p10 + p2 + p13 + p11 + p15 + p19 + p18 | 1.000 | 0.846 | 1.000 | 0.389 | 0.923 | 0.684 |
| 13 | class~age + sex + p16 + p20 + p6 + p9 + p22 + p10 + p2 + p14 + p13 + p11 + p15 + p19 + p18 | 1.000 | 0.846 | 1.000 | 0.000 | 1.000 | 0.654 |
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| Number of Variables | Model | Train Set | Cross-Validation (CV) Set | ||||
| Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | ||
| 0 | class~age + sex | 0.3111 | 0.8462 | 0.5976 | 0.2056 | 0.8462 | 0.5314 |
| 1 | class~age + sex + g150 | 0.9444 | 0.8462 | 0.9615 | 0.9444 | 0.8462 | 0.9299 |
| 2 | class~age + sex + g150 + g64 | 1.0000 | 0.8462 | 1.0000 | 0.9500 | 0.9231 | 0.9515 |
| 3 | class~age + sex + g150 + g64 + g22 | 1.0000 | 0.8462 | 1.0000 | 1.0000 | 0.9231 | 0.9957 |
| 4 | class~age + sex + g15 + g150 + g64+g22 | 1.0000 | 0.8462 | 1.0000 | 0.9444 | 0.9231 | 0.9594 |
| 5 | class~age + sex + g15 + g150 + g64 + g225 + g22 | 1.0000 | 0.8462 | 1.0000 | 0.9444 | 0.9231 | 0.9594 |
| 6 | class~age + sex + g210 + g23 + g150 + g64 + g225 + g22 | 1.0000 | 0.8462 | 1.0000 | 1.0000 | 0.9231 | 0.9829 |
| 7 | class~age + sex + g49 + g15 + g210 + g150 + g64 + g225 + g22 | 1.0000 | 0.8462 | 1.0000 | 1.0000 | 0.9231 | 1.0000 |
| 8 | class~age + sex + g19 + g49 + g15 + g210 + g150 + g64 + g225 + g22 | 1.0000 | 0.8462 | 1.0000 | 0.8444 | 0.8846 | 0.9034 |
| 9 | class~age + sex + g19 + g49 + g15 + g210 + g23 + g150 + g64 + g225 + g22 | 1.0000 | 0.8462 | 1.0000 | 0.7944 | 0.8462 | 0.8613 |
| 10 | class~age + sex + g19 + g49 + g15 + g210 + g23 + g150 + g59 + g64 + g225 + g22 | 1.0000 | 0.8462 | 1.0000 | 0.3500 | 0.9231 | 0.8338 |
The finally selected model was highlighted as bold. The OTU symbols are as follows: p16, Verrucomicrobia; p6, Actinobacteria; g49, Sphingomonas; g15, Ruminococcaceae UCG-014; g210, Propionibacterium; g150, Akkermansia; g64, Ruminiclostridium; g225, Lachnospiraceae UCG-001; g22, Corynebacterium 1.