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. 2021 Mar 11;22(6):2836. doi: 10.3390/ijms22062836

Figure 5.

Figure 5

Skin coloring 12 h after removal of BNC–DHA patches (concentration of DHA is expressed in percent), applied for 30 min (a) (reprinted with permission from [110]); Schematic representation of the HA-(BNC-R) MNs structure (b) and functioning of this innovative system: insertion of the MNs into the skin, dissolution of HA MNs and subsequent release of the bioactive molecule from the BNC membrane (c) (reprinted with permission from [119]). DHA: 1,3-dihydroxy-2-propanone, HA: hyaluronic acid, MN: microneedles, R: rutin.