Table 1.

Drugs currently associated with drug-induced liver injury (DILI).

Drug	Indication	Type	Drug	Indication	Type
Abacavir	Antiretroviral	H/C	Allopurinol	Gout prophylaxis	H
Amiodarone	Anti-arrhythmic	H	Amodiaquine	Malaria treatment	H
Amoxicillin–clavulanic acid	Antibiotic	C/M	Angiotensin -converting enzyme inhibitors	Hypertension	C
Atorvastatin	Hypercholesterolemia	H/C	Azathioprine	Immunosuppressor	C
Bosentan	Hypertension	H/M	Carbamazepine	Anticonvulsant	H/C/M
Chlorpromazine	Antipsychotic	C/M	Clozapine	Antipsychotic	H/M
Cyclosporine A	Immunosuppressor	C	Dantrolene	Muscle relaxant	H
Diclofenac	Analgesic	H	Disulfiram	Alcoholism	H
Erythromycin	Antibiotic	C/M	Felbamate	Anticonvulsant	H
Fenofibrate	Hypertriglyceridemia and dyslipidemia	H	Floxuridine	Antineoplastic	H/C
Flucloxacillin	Antibiotic	C	Flupirtine	Analgesic	H
Flutamide	Nonsteroidal antiandrogen	H/C/M	Gabapentin	Anticonvulsant	C
Halothane	Anesthetic	H	Hydralazine	Antihypertensive	H
Ibuprofen	NSAID	H	Infliximab	Monoclonal antibody (Crohn’s disease, rheumatoid arthritis)	H
Isoniazid	Anti-tuberculotic	H	Ketoconazole	Fungicidal	H/C
Lamotrigine	Anticonvulsant	H	Lapatinib	Breast cancer	H
Leflunomide	Immunomodulatory agent	H/C	Lisinopril	Antihypertensive	H
Methotrexate	Antineoplastic	H	Methyldopa	Antihypertensive	H
Minocycline	Antibiotic	H	Nefazodone	Antidepressant	H
Nevirapine	Nonnucleoside reverse transcriptase inhibitor	C	Nitrofurantoin	Antibiotic	H/M
Pazopanib	Antitumor activity	M	Phenytoin	Anticonvulsant	H/M
Propylthiouracil	Antithyroid	H	Pyrazinamide	Anti-tuberculotic	H
Quinidine	Antiarrhythmic	C/M	Rifampicin	Anti-tuberculotic	H
Statins	Hypolipidemic	H/C	Sulfasalazine	Antirheumatic	M
Sulfonamides	Antibiotic	H/C	Sulindac	NSAID	H/C/M
Tamoxifen	Nonsteroidal antiestrogen	H/C/M	Terbinafine	Fungicidal	H/C
Thioguanine	Antitumor activity	M	Ticlopidine	Anti-platelet	C
TMP-SMX	Antibiotic	H	Tolcapone	Parkinson’s disease therapy	H
Tolvaptan	Hyponatremia treatment	H/M	Valproic acid	Anticonvulsant	H

H (hepatocellular), C (cholestatic), M (mixed). No data shown for withdrawn drugs. Updated information on the diagnosis, cause, frequency and patterns of liver injury induced by both prescription and non-prescription medications can be consulted in LiverTox (http://livertox.nlm.nih.gov, accessed on 8 January 2021). Moreover, categorization of drugs associated to DILI based on documented hepatotoxicity in the literature is available [22].