Figure 5.

ImmunoPET–CT of MT1-MMP metalloproteinase in a preclinical model of PDAC. (A) Coronal, (B) axial, and (C) sagittal views of fused Immuno-PET and CT images of an orthotopic pancreatic patient-derived xenograft mouse. White arrows indicate tumor location. The imaging probe used was [⁸⁹Zr]Zr-DFO-LEM2/15, a mAb developed against the MT1-MMP metalloproteinase [107]. Owing to the central role that this metalloproteinase plays in collagen-induced gemcitabine resistance, this probe could be used for the early prediction of resistance to gemcitabine in metastatic PDAC patients.