Table 1.
Serotonin Receptor Subtypes. Serotonin receptors vary in expression in target tissues and are implicated in a variety of disorders [45,46].
| Receptor Subtype | Primary Locations | Implicated Disorders |
|---|---|---|
| 5-HT1A | CNS (Median raphe nuclei; septal nuclei; hippocampus; neocortex) | Anxiety and depression |
| 5-HT1B | CNS (Ventral pallidum; substantia nigra), intracranial vasculature | Migraine |
| 5-HT1D | CNS (Ventral pallidum; substantia nigra), intracranial vasculature | Migraine |
| 5-HT1E | CNS (Olfactory bulb; hippocampus; neocortex; striatum) | ? |
| 5-HTF | CNS (Trigeminal ganglia; neocortex; hippocampus; astroglia), PNS (Dorsal root ganglia), Renal proximal tubule, coronary artery, pulmonary artery | Migraine |
| 5-HT2A | CNS (Neocortex); vascular smooth muscle | Psychosis, schizophrenia, hypertension |
| 5-HT2B | Cardiac Fibroblasts, stomach | Heart failure, anxiety, pulmonary hypertension |
| 5-HT2C (formerly 5-HT1C) | CNS (Choroid plexus) | Obesity, epilepsy, psychosis, mood disorders, anxiety |
| 5-HT3 | CNS (Substantia gelatinosa; area postrema) | Nausea and vomiting |
| 5-HT4 | CNS (Hippocampus; colliculi), GI tract | GI motility disorders |
| 5-HT5 | CNS (Hippocampus) | Sleep disorders |
| 5-HT6 | CNS (Striatum; neocortex; limbic system) | Cognitive disorders, obesity, seizures |
| 5-HT7 | CNS (Suprachiasmatic nucleus; hippocampus; thalamus) | Anxiety, sleep disorders, cognitive disorders |