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A non-angiogenic lung metastases from an osteosarcoma presented by Rupert A. Wills in his 1934 book The Spread of the Tumours in the Human Body. In the words of the author: “Sections of a pulmonary metastasis showing alveoli occupied by plugs of growth resembling osteoid tissue. Note the strands of growth connecting the alveolar plugs trough the septal pores.” (arrow).
